Description

Amg 458 is a high-purity, small-molecule chemical compound identified by the CAS registry number 913376-83-7. This compound is valued in advanced research and development for its specific biological activity and utility as a key intermediate in synthetic pathways. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and specialized chemical manufacturers engaged in the development of novel therapeutic agents and biochemical probes.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of investigational new drugs.
• Biochemical Research: Used as a reference standard or a tool compound in enzymatic assays and target validation studies.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate pharmacokinetic and pharmacodynamic properties.
• Chemical Synthesis: Acts as a versatile building block for creating more complex molecular structures in medicinal chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	Amg 458
CAS No.	913376-83-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	AMG-458; AMG458; 913376-83-7; 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide; N-Methyl-4-[4-[[[3-[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-2-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our Amg 458 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.