Description

Onalespib is a potent and selective small-molecule inhibitor of heat shock protein 90 (Hsp90). This compound matters as a critical research tool for investigating protein folding, client protein degradation, and oncogenic signaling pathways in various cancers. Pharmaceutical R&D laboratories and academic institutions require Onalespib CAS NO 912999-49-6 for preclinical studies in oncology, neurodegenerative diseases, and other conditions where Hsp90 plays a key pathological role.

Application

• Biomedical Research: Used as a reference standard and active agent in cancer biology studies, particularly for investigating breast cancer, multiple myeloma, and glioblastoma.
• Drug Discovery & Development: Serves as a key pharmacological probe for validating Hsp90 as a therapeutic target and for screening combination therapies.
• Mechanistic Studies: Employed to study the chaperone function of Hsp90 and its role in stabilizing oncoproteins like HER2, AKT, and mutant p53.
• Preclinical In Vitro/In Vivo Models: Essential for evaluating anti-tumor efficacy, pharmacokinetics, and pharmacodynamics in animal models of disease.
• Apoptosis & Autophagy Research: A tool for inducing programmed cell death in cancer cell lines through the disruption of Hsp90-client protein interactions.
• Synergistic Therapy Development: Investigated in combination with other targeted agents or chemotherapeutics to overcome drug resistance.

Basic Information

Product Name	Onalespib
CAS No.	912999-49-6
Molecular Formula	C31H33N5O4S
Molecular Weight	571.69 g/mol
Synonyms	AT-13387; AT13387; (2E)-N,N-Dimethyl-3-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-2-propenamide; 2-Propenamide, N,N-dimethyl-3-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-, (2E)-; Onalespib (AT13387); AT-13387 (Onalespib); Hsp90 Inhibitor AT13387
EINECS	Contact for details

Quality Control

Our Onalespib is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support preclinical and development activities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.