Description

Veliparib is a potent and selective small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, primarily PARP-1 and PARP-2. This compound matters significantly as a key research tool and pharmaceutical intermediate in the development of targeted cancer therapies, particularly for tumors with deficiencies in DNA repair pathways such as BRCA-mutated cancers. It is essential for pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) engaged in oncology drug discovery and development.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis of finished drug products for clinical and commercial use.
• Oncology Research: Used as a reference standard and active agent in preclinical studies to investigate PARP inhibition, synthetic lethality, and combination therapies.
• Biochemical Assay Development: Serves as a potent inhibitor in enzymatic assays to study PARP activity and screen for novel drug candidates.
• Academic & Institutional Research: Utilized in university and hospital labs for fundamental cancer biology research and mechanism-of-action studies.
• Clinical Trial Material (CTM) Manufacturing: Supplied under GMP conditions for the production of batches used in human clinical trials.
• Combination Therapy Studies: Investigated in research for its synergistic effects with chemotherapy, radiation, and other targeted agents.

Basic Information

Product Name	Veliparib
CAS No.	912444-00-9
Molecular Formula	C13H16N4O
Molecular Weight	244.29 g/mol
Synonyms	ABT-888; 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide; (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide; PARP Inhibitor ABT-888; Veliparib (ABT-888); BRN 2248840
EINECS	Contact for details

Quality Control

Our Veliparib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.