Description

Ly2603618 is a potent and selective small molecule inhibitor targeting key pathways in cellular regulation. This high-purity compound is essential for advanced research and development in life sciences, offering reliable and consistent performance for critical applications. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology research, kinase biology studies, and preclinical drug discovery programs.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents.
• Oncology and Kinase Biology Studies: Used as a selective chemical probe to investigate specific kinase signaling pathways and their role in cancer cell proliferation and survival.
• Preclinical Drug Discovery: Employed in in vitro and in vivo studies to validate drug targets and assess the efficacy of new drug candidates.
• Biochemical Assay Development: Acts as a key component in high-throughput screening (HTS) campaigns and the development of functional assays for target validation.
• Academic Research: Supports fundamental research in cell signaling, molecular biology, and medicinal chemistry at universities and research institutes.

Basic Information

Product Name	Ly2603618
CAS No.	911222-45-2
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	LY2603618; 8-(4-(4-(1H-Pyrazol-4-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-morpholino-4-oxo-4H-chromene-3-carbonitrile; CHK1 Inhibitor II; 4H-1-Benzopyran-3-carbonitrile, 8-[4-[4-(1H-pyrazol-4-yl)phenyl]-3,6-dihydro-1(2H)-pyridinyl]-2-(4-morpholinyl)-4-oxo-; Prexasertib dihydrochloride (LY2606368) precursor; Checkpoint kinase 1 (CHK1) inhibitor.
EINECS	Contact for details

Quality Control

Our Ly2603618 is manufactured under strict quality management systems to ensure the highest standards of purity and consistency. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.