Description

T-Boc-n-Amido-Peg5-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (Boc)-protected amine at one terminus and an azide group at the other. This compound is engineered to facilitate the controlled conjugation of biomolecules and other functional entities, enabling the creation of stable, well-defined constructs. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where precise molecular assembly is paramount.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) research and production.
• PEGylation of Peptides and Proteins: Serves as a spacer to improve solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Click Chemistry: The terminal azide group enables efficient, site-specific conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) reactions.
• Polymer and Materials Science: Acts as a functional building block for synthesizing smart hydrogels, surface coatings, and functionalized nanoparticles.
• Prodrug Synthesis: Utilized to create cleavable linkers for prodrug strategies, where the Boc-protected amine allows for subsequent deprotection and attachment of targeting moieties.
• Diagnostic Reagent Preparation: Employed in the development of fluorescent probes and imaging agents for diagnostic applications.

Basic Information

Product Name	T-Boc-n-Amido-Peg5-Azide
CAS No.	911209-07-9
Molecular Formula	C24H46N4O9
Molecular Weight	534.65 g/mol
Synonyms	1-Boc-amino-3,6,9,12,15-pentaoxa-18-azaoctadecan-18-azide; 2,5,8,11,14-Pentaoxa-17-azaheptadecan-17-azide, 1-[(1,1-dimethylethoxy)carbonyl]amino]-; Boc-NH-PEG5-N3; tert-Butyl (17-azido-3,6,9,12,15-pentaoxa-17-azaheptadecyl)carbamate; Azido-PEG5-amine Boc; Boc-Amine-PEG5-Azide; N-Boc-1-amino-3,6,9,12,15-pentaoxa-18-azaoctadecane-18-azide
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg5-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage, consider storing under an inert atmosphere. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.