Description

3-(Hexadecyloxy)Propyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonat is a sophisticated nucleotide-lipid conjugate, representing a key intermediate in advanced pharmaceutical and biochemical research. This compound is specifically engineered to enhance the delivery and cellular uptake of nucleoside analogs, making it a critical component for developing targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies focused on antiviral drug development, oligonucleotide delivery systems, and lipid nanoparticle (LNP) formulation for mRNA and gene therapies.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel prodrugs and nucleotide analogs with enhanced bioavailability.
• Lipid Nanoparticle (LNP) Formulation: Serves as an ionizable or helper lipid component for the encapsulation and delivery of mRNA, siRNA, and other nucleic acid therapeutics.
• Antiviral Research: Used in the development of nucleoside phosphonate prodrugs targeting viruses such as hepatitis B (HBV), HIV, and other viral pathogens.
• Bioconjugation & Prodrug Synthesis: Enables the creation of targeted drug delivery systems by conjugating therapeutic nucleosides to lipid moieties.
• Biochemical Tool Compound: Employed in academic and industrial research to study membrane permeability and intracellular trafficking mechanisms.
• Gene Therapy Development: A functional material for non-viral vector systems designed to improve transfection efficiency and reduce cytotoxicity.

Basic Information

Product Name	3-(Hexadecyloxy)Propyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonat
CAS No.	911208-73-6
Molecular Formula	C28H50N5O5P
Molecular Weight	567.70 g/mol
Synonyms	1-O-Hexadecyl-2-O-((R)-9-(2-hydroxypropyl)adenin-9-yl)propane-1,3-diyl phosphonate; (R)-HPMPA 1-O-Hexadecyl Ether; Hexadecyloxypropyl-(R)-HPMPA; C16-HPMPA; HDP-(R)-HPMPA; Lipid-conjugated (R)-HPMPA; Nucleoside phosphonate lipid conjugate; 911208-73-6
EINECS	Contact for details

Quality Control

Every batch of our 3-(Hexadecyloxy)Propyl Hydrogen ((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl)Phosphonat is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.