Description

n-(2-Chloro-4-Hydroxy-6-Methylphenyl)-2-[[6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting specific enzymatic pathways. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic targets.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the development of selective kinase inhibitors due to its pyrimidine and thiazole motifs.
• Biochemical Assay Standard: Can be utilized as a reference standard or inhibitor in high-throughput screening (HTS) and biochemical assays.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for advanced studies in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	n-(2-Chloro-4-Hydroxy-6-Methylphenyl)-2-[[6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxamide
CAS No.	910297-57-3
Molecular Formula	C22H26ClN7O3S
Molecular Weight	504.01 g/mol
Synonyms	2-[(6-{4-(2-Hydroxyethyl)piperazin-1-yl}-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-4-hydroxy-6-methylphenyl)-1,3-thiazole-5-carboxamide; 910297-57-3; UNII-8V7B3G8K4H; Thiazolecarboxamide derivative; Kinase inhibitor intermediate; PI3K/mTOR inhibitor intermediate; Compound 910297-57-3
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-4-Hydroxy-6-Methylphenyl)-2-[[6-[4-(2-Hydroxyethyl)-1-Piperazinyl]-2-Methyl-4-Pyrimidinyl]Amino]-5-Thiazolecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.