Description

Dasatinib n-Oxide is a key pharmaceutical intermediate and metabolite of the tyrosine kinase inhibitor Dasatinib. This compound is of significant importance in the research and development of targeted cancer therapies, particularly for chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for analytical reference standards, metabolic studies, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of Dasatinib and its related substances in drug products and biological matrices.
• Metabolite Research: Critical for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, and Excretion) studies to understand the metabolic pathways and pharmacokinetics of Dasatinib.
• Impurity Profiling: Used as an analytical standard to monitor and control the level of oxidative degradation impurities during the synthesis, formulation, and stability testing of Dasatinib API.
• Process Development & Validation: Employed in the development and validation of analytical methods (e.g., HPLC, LC-MS) for quality control in API manufacturing.
• Biochemical Research: Utilized in enzymatic and cellular assays to study the biological activity and inhibition profile of Dasatinib metabolites.

Basic Information

Product Name	Dasatinib n-Oxide
CAS No.	910297-52-8
Molecular Formula	C22H26ClN7O3S
Molecular Weight	528.01 g/mol
Synonyms	BMS-354825 n-Oxide; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide 1-Oxide; Dasatinib Metabolite; Dasatinib N-Oxide Metabolite; Dasatinib Related Compound; Sprycel n-Oxide
EINECS	Contact for details

Quality Control

Our Dasatinib n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures material suitable for demanding pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.