Description

2'-Deoxy-5'-o-Dmt-N2-(4-Isopropylphenoxyacetyl)Guanosine is a high-purity, protected nucleoside phosphoramidite precursor, a critical building block in automated oligonucleotide synthesis. This compound is essential for the precise and efficient assembly of DNA sequences, particularly in the synthesis of antisense oligonucleotides, primers, and probes. It is primarily utilized by research institutions, diagnostic developers, and pharmaceutical companies engaged in molecular biology, genomics, and therapeutic nucleic acid development.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of custom DNA strands.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense drugs, siRNA, and aptamers for targeted therapies.
• Diagnostic Probe Development: Synthesis of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Genomics Research: Creation of primers and gene fragments for sequencing, cloning, and mutagenesis studies.
• Synthetic Biology: Construction of artificial genes and genetic circuits requiring high-fidelity DNA components.
• Bioconjugation & Labeling: Serves as a modified nucleoside intermediate for introducing specific functional groups or labels into oligonucleotides.

Basic Information

Product Name	2'-Deoxy-5'-o-Dmt-N2-(4-Isopropylphenoxyacetyl)Guanosine
CAS No.	909415-65-2
Molecular Formula	C41H47N5O9
Molecular Weight	753.85 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-N2-[4-(1-methylethyl)phenoxyacetyl]guanosine; DMT-dG(ipr-Pac) Phosphoramidite precursor; N2-(4-Isopropylphenoxyacetyl)-5'-O-DMT-2'-deoxyguanosine; Guanosine, 2'-deoxy-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N2-[4-(1-methylethyl)phenoxy]acetyl]-; Protected dG Phosphoramidite Monomer; ipr-Pac-dG(DMT)
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5'-o-Dmt-N2-(4-Isopropylphenoxyacetyl)Guanosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to GMP principles for production and control, ensuring the material meets the stringent requirements for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C ± 5°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.