Description

S-22611, Epertinib is a potent and selective small molecule kinase inhibitor with significant research and development applications. This high-purity compound is critical for advancing studies in targeted cancer therapy and signal transduction pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in oncology drug discovery and preclinical development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel oncology therapeutics.
• Kinase Inhibition Studies: Used as a selective inhibitor in biochemical and cellular assays to study specific kinase signaling pathways and their role in disease progression.
• Preclinical Evaluation: Essential for in vitro and in vivo studies to assess the efficacy, pharmacokinetics, and pharmacodynamics of EGFR/HER2 targeting agents.
• Analytical Method Development: Employed as a high-purity standard for developing and validating HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Chemical Biology: A valuable tool compound for probing protein function and understanding the mechanisms of action of tyrosine kinase inhibitors.

Basic Information

Product Name	S-22611, Epertinib
CAS No.	908305-13-5
Molecular Formula	C30H34N6O3
Molecular Weight	526.63 g/mol
Synonyms	Epertinib; S-222611; TAS-0728; (R,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide; UNII-4F8W21Y9U8; 4F8W21Y9U8; BDBM50391425; CHEMBL2103875
EINECS	Contact for details

Quality Control

Our S-22611, Epertinib is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, LC-MS, and NMR. We adhere to cGMP guidelines where applicable for API intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.