Description

Crisaborole CAS NO 906673-24-3 is a boron-containing small molecule pharmaceutical compound that functions as a potent and selective phosphodiesterase 4 (PDE4) inhibitor. This mechanism of action makes it a critical active pharmaceutical ingredient (API) for modulating inflammatory responses in dermatological conditions. It is primarily required by pharmaceutical manufacturers and research institutions developing and producing topical treatments for inflammatory skin diseases.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical ointments for the treatment of mild to moderate atopic dermatitis (eczema).
• Key Intermediate in advanced pharmaceutical synthesis and research into novel PDE4 inhibitor therapies.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Research Chemical for preclinical and clinical studies exploring new anti-inflammatory applications.
• Formulation Development for creating new topical drug delivery systems and combination products.

Basic Information

Product Name	Crisaborole
CAS No.	906673-24-3
Molecular Formula	C14H10BNO3
Molecular Weight	251.05 g/mol
Synonyms	AN-2728; 5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole; 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile; Eucrisa (Trade Name); Crisaborole Topical; PDE4 Inhibitor AN2728
EINECS	Contact for details

Quality Control

Our Crisaborole is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to confirm compliance with in-house specifications aligned with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and quality assurance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.