Description

(Z)-Crotamiton is a specific geometric isomer of the antipruritic agent crotamiton, distinguished by its Z-configuration around the double bond. This precise stereochemistry is critical for its intended applications in pharmaceutical research and development, where molecular specificity directly impacts biological activity and regulatory approval. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and fine chemical sectors focused on dermatological treatments and novel API synthesis.

Application

• Primary intermediate in the synthesis of the active pharmaceutical ingredient (API) Crotamiton.
• Key starting material (KSM) or building block for pharmaceutical research and development.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Used in preclinical and clinical research studies investigating antipruritic (anti-itch) agents.
• Intermediate in the production of specialized fine chemicals for dermatological applications.
• Building block for chemical synthesis in academic and industrial research laboratories.

Basic Information

Product Name	(Z)-Crotamiton
CAS No.	124236-30-2
Molecular Formula	C13H17NO
Molecular Weight	203.28 g/mol
Synonyms	(Z)-N-Ethyl-N-(2-methylphenyl)but-2-enamide; (Z)-Crotamiton Isomer; cis-Crotamiton; (Z)-N-Ethyl-o-methylcrotonotoluidide; (2Z)-N-Ethyl-N-(2-methylphenyl)but-2-enamide; Geometric Isomer of Crotamiton; (Z)-Isomer of Crotamiton
EINECS	Contact for details

Quality Control

Our (Z)-Crotamiton is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.