Description

Trifarotene CAS NO 895542-09-3 is a synthetic, fourth-generation topical retinoid specifically designed for targeted receptor activity. This compound is of significant commercial and therapeutic interest due to its high selectivity for the retinoic acid receptor gamma (RAR-γ), which is predominant in the skin. It is primarily utilized by the pharmaceutical industry for the development of novel dermatological treatments, offering a refined approach to managing specific skin conditions with an improved tolerability profile.

Application

• Active Pharmaceutical Ingredient (API) in prescription topical creams and gels for acne vulgaris.
• Key Intermediate in advanced pharmaceutical research and development for new retinoid-based therapies.
• Dermatological R&D for studying cellular differentiation and proliferation in skin models.
• Formulation Development for stable and efficacious topical drug products requiring precise retinoid activity.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Trifarotene
CAS No.	895542-09-3
Molecular Formula	C₂₄H₂₅F₃O₄
Molecular Weight	434.45 g/mol
Synonyms	CD5789; Aklief (as API); 4-[3-tert-Butyl-5-(2,2,2-trifluoroethoxy)phenyl]-2-hydroxyphenyl methanesulfonate; 4-[3-(1,1-Dimethylethyl)-5-[(2,2,2-trifluoroethoxy)methyl]phenoxy]-2-hydroxybenzenemethanesulfonate; Trifaroten; Trifaroteno; RAR-γ selective agonist.
EINECS	Contact for details

Quality Control

Our Trifarotene is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for use under cGMP conditions for drug substance manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.