Description

Acitretin is a synthetic second-generation retinoid used primarily as an active pharmaceutical ingredient (API). This compound is critical for the treatment of severe dermatological conditions, offering a targeted therapeutic approach. It is essential for pharmaceutical manufacturers and research institutions developing formulations for psoriasis and other keratinization disorders. Our supply ensures high purity and consistent quality for global pharmaceutical applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in oral medications for severe psoriasis.
• Dermatological Treatments: Formulation of therapies for other disorders of keratinization, such as Darier's disease and lichen planus.
• Clinical Research: Use in preclinical and clinical studies investigating retinoid pathways and new therapeutic applications.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories in the pharmaceutical industry.
• Drug Development: A key intermediate or model compound in the R&D of novel retinoid-based therapies.

Basic Information

Product Name	Acitretin
CAS No.	55079-83-9
Molecular Formula	C21H26O3
Molecular Weight	326.43 g/mol
Synonyms	Neotigason; Etretin; Ro 10-1670; all-trans-Acitretin; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; Acretin; 13-cis-Acitretin (Isomer); Soriatane (Brand Name)
EINECS	Contact for details

Quality Control

Our Acitretin is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical use, with comprehensive analysis including identity, assay, and impurity profiling. Certificates of Analysis (COA) are provided, detailing compliance with in-house specifications aligned with ICH guidelines. We support audits and can provide regulatory documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen) at a controlled room temperature of 15-25°C to minimize oxidation and ensure stability. The container should be kept in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.