Description

Crotamiton CAS NO 483-63-6 is a synthetic organic compound primarily recognized for its antipruritic and scabicidal properties. This versatile active pharmaceutical ingredient (API) is essential for formulating effective topical treatments for parasitic skin infestations and severe itching. It is a critical raw material for pharmaceutical manufacturers, dermatological research institutions, and compounding pharmacies focused on dermatological health.

Application

• Primary Pharmaceutical Use: As the active ingredient in topical creams and lotions for the treatment of scabies (Sarcoptes scabiei infestation).
• Antipruritic Formulations: Incorporated into medicated creams to provide relief from intense itching (pruritus) associated with various skin conditions, including allergic reactions and eczema.
• Veterinary Medicine: Used in topical preparations for managing parasitic mite infestations in animals.
• API for Generic Drugs: Sourced by generic pharmaceutical companies for the production of cost-effective antiparasitic medications.
• Dermatological Research: Serves as a reference standard and key component in R&D for novel transdermal delivery systems and anti-itch therapies.

Basic Information

Product Name	Crotamiton
CAS No.	483-63-6
Molecular Formula	C13H17NO
Molecular Weight	203.28 g/mol
Synonyms	N-Ethyl-N-(2-methylphenyl)-2-butenamide; N-Ethyl-o-crotonotoluidide; Crotamitone; Eurax (Trade Name); (2E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide; o-Crotonotoluidide, N-Ethyl-; NSC 33583
EINECS	207-612-1

Quality Control

Our Crotamiton is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical actives. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with various pharmacopeial standards, including in-house specifications tailored to your formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow oily liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.