Description

Azide-Peg6-Tos is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a tosylate leaving group, separated by a hexaethylene glycol spacer. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient and site-specific modification of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science to create targeted drug delivery systems, diagnostic probes, and functionalized hydrogels.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: The azide group enables copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-modified drugs or toxins, while the tosylate reacts with nucleophiles (e.g., thiols, amines) on antibodies or proteins.
• Polymer and Dendrimer Functionalization: Used to introduce azide handles onto polymer backends or nanoparticle surfaces for subsequent "click" coupling with alkyne-bearing ligands, dyes, or other functional groups.
• Surface Modification and Biointerface Engineering: The tosylate end can be used to graft the linker onto amine- or thiol-coated surfaces (e.g., chips, beads), presenting azide groups for immobilizing alkyne-tagged biomolecules in microarray and biosensor applications.
• Crosslinking Agent for Hydrogel Formation: Acts as a versatile crosslinker where one end reacts with a functional group on a polymer chain and the other end participates in bio-orthogonal click chemistry to form tunable, biocompatible networks.
• Synthesis of PEGylated Prodrugs: Facilitates the creation of prodrugs by linking a drug molecule via the tosylate group and a targeting moiety via the azide group, leveraging the PEG spacer for improved solubility and pharmacokinetics.
• Chemical Biology Probe Development: Essential for creating activity-based probes where the tosylate acts as a reactive warhead for active site labeling, and the azide allows for reporter tag attachment via click chemistry.

Basic Information

Item	Details
Product Name	Azide-Peg6-Tos
CAS No.	906007-10-1
Molecular Formula	C25H43N3O9S
Molecular Weight	561.69 g/mol
Synonyms	Azido-PEG6-tosylate; 2,5,8,11,14,17-Hexaoxanonadecan-19-yl 4-methylbenzenesulfonate, 19-azido; Tos-PEG6-N3; 1-Azido-3,6,9,12,15,18-hexaoxahenicosan-21-yl 4-methylbenzenesulfonate; N3-PEG6-OTs; Azidohexaethyleneglycol tosylate; PEG6-Azide Tosylate; Heterobifunctional PEG linker Azide-PEG6-OTs
EINECS	Contact for details

Quality Control

Our Azide-Peg6-Tos is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry to ensure identity and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay purity, water content, and residual solvents. Our quality commitment supports applications in GMP-compatible research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Complies with structure
Identification (MS)	Complies (M+Na)+
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.