Description

Pevonedistat CAS NO 905579-51-3 is a potent, selective, and first-in-class small molecule inhibitor of the NEDD8-activating enzyme (NAE), a key component of the neddylation pathway. This targeted mechanism of action makes it a critical research tool and a promising therapeutic candidate for disrupting protein homeostasis in cancer cells. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biotech companies engaged in oncology drug discovery and development, particularly for hematological malignancies and solid tumors.

Application

• Oncology Research & Drug Discovery: A key investigational compound for studying the role of protein neddylation in cancer cell proliferation and survival.
• Preclinical Development: Used in in vitro and in vivo studies to validate NAE as a therapeutic target and assess antitumor efficacy.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) assays targeting the ubiquitin-proteasome system.
• Combination Therapy Studies: Investigated in research for potential synergistic effects when combined with other chemotherapeutic agents or targeted therapies.
• Mechanism of Action (MoA) Studies: Essential for elucidating the downstream effects of NAE inhibition on cullin-RING ligase (CRL) function and substrate protein degradation.
• API Intermediate: Used as an active pharmaceutical ingredient (API) intermediate in the synthesis and development of novel anticancer therapeutics.

Basic Information

Product Name	Pevonedistat
CAS No.	905579-51-3
Molecular Formula	C₂₀H₂₆N₄O₄S
Molecular Weight	418.51 g/mol
Synonyms	MLN4924; TAK-924; NAE Inhibitor MLN4924; (1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate; Nedd8-Activating Enzyme Inhibitor MLN4924; (1S,2S,4R)-4-[4-[[(1S)-2,3-Dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamate
EINECS	Contact for details

Quality Control

Our Pevonedistat is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.