Description

n-Acetyl Amphotericin B is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This modification enhances certain physicochemical properties, making it a valuable intermediate for advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for creating novel therapeutic formulations and conducting structure-activity relationship studies. The compound is critical for developing next-generation antifungal agents and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of novel antifungal drugs and prodrugs.
• Biomedical Research: Used in academic and industrial laboratories to study the mechanism of action, toxicity, and efficacy of polyene antibiotics.
• Drug Delivery System Development: Employed in the formulation of liposomal, nanoparticle, or other advanced carrier systems to improve therapeutic index.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to modify the amphotericin B scaffold to reduce toxicity or enhance selectivity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	n-Acetyl Amphotericin B
CAS No.	902457-23-2
Molecular Formula	C49H75NO19
Molecular Weight	982.11 g/mol
Synonyms	N-Acetyl Amphotericin B; Amphotericin B N-Acetate; 16-Acetylamphotericin B; 1-Acetylamphotericin B; Amphotericin B Acetate (derivative); Acetylated Amphotericin B; Polyene Antibiotic Derivative; Antifungal Intermediate
EINECS	Contact for details

Quality Control

Our n-Acetyl Amphotericin B is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.