Description

2'-Deoxy-8,2'-Methylene-Cycloguanosine is a chemically modified nucleoside analog, representing a sophisticated building block in advanced pharmaceutical research. This compound is valued for its unique bridged structure, which imparts specific biochemical properties crucial for probing enzyme mechanisms and developing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, nucleotide biochemistry, and the synthesis of high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of nucleoside-metabolizing enzymes like kinases and polymerases.
• Probe Development: Employed in the design of molecular probes for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Medicinal Chemistry: Provides a structurally constrained scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2'-Deoxy-8,2'-Methylene-Cycloguanosine
CAS No.	99921-84-3
Molecular Formula	C11H13N5O4
Molecular Weight	279.25 g/mol
Synonyms	8,2'-Methylene-2'-deoxyguanosine; 2'-Deoxy-8,2'-methanoguanosine; Cycloguanosine derivative; Bridged deoxyguanosine analog; 9-[(2R,4S,5R)-4-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-1H,8H-2,6-methanoimidazo[1,2-a][1,3,5]triazocin-1-one; 2'-Deoxy-8,2'-cycloguanosine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-8,2'-Methylene-Cycloguanosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.