Description

2'-Deoxy-8,2'-Methylene-Cycloadenosine is a chemically modified nucleoside analog, characterized by a unique methylene bridge between the 8 and 2' positions of the adenine ring system. This structural modification is of significant interest in medicinal chemistry and biochemical research for its potential to modulate biological activity and stability. It serves as a valuable building block and reference standard for pharmaceutical R&D, particularly in the development of antiviral and anticancer therapeutics, as well as in fundamental studies of nucleic acid chemistry and enzymology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies to investigate the mechanisms of polymerases, nucleotidyltransferases, and other nucleic acid-metabolizing enzymes.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of the 8,2'-methylene bridge on binding affinity, metabolic stability, and biological potency.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis using HPLC, LC-MS, or NMR.
• Academic Research: A tool compound for studying altered sugar conformation and its effects on nucleic acid duplex stability and recognition.

Basic Information

Product Name	2'-Deoxy-8,2'-Methylene-Cycloadenosine
CAS No.	99901-17-4
Molecular Formula	C11H13N5O3
Molecular Weight	263.25 g/mol
Synonyms	8,2'-Methanoadenosine, 2'-deoxy-; 2'-Deoxy-8,2'-methanoadenosine; 8,2'-Methylene-2'-deoxyadenosine; Cycloadenosine, 2'-deoxy-8,2'-methylene-; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-8,2-methano-8H-purin-6-amine; 2'-Deoxy-8,2'-cycloadenosine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-8,2'-Methylene-Cycloadenosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent in-house quality standards, with testing typically including HPLC for assay and related substances, NMR and IR for structural confirmation, and loss on drying for moisture content. Specifications can be aligned with client requirements for specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect stability and purity. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.