Description

8,2'-Ethano-Cyclo-2'-Deoxyadenosine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. Its unique bridged structure makes it a valuable intermediate for developing novel therapeutic agents, particularly in antiviral and anticancer drug discovery. This high-purity compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleotide-based therapies and molecular probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in the development of next-generation antiviral agents, leveraging its modified deoxyadenosine scaffold.
• Biochemical Probe Development: Serves as a specialized substrate or inhibitor in enzymatic studies and mechanism-of-action research.
• Nucleic Acid Chemistry: Employed in the synthesis of modified oligonucleotides for diagnostic applications and structural biology studies.
• Medicinal Chemistry & SAR Studies: A key compound for structure-activity relationship (SAR) analysis to optimize drug potency and selectivity.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Item	Detail
Product Name	8,2'-Ethano-Cyclo-2'-Deoxyadenosine
CAS No.	99901-16-3
Molecular Formula	C₁₂H₁₅N₅O₃
Molecular Weight	277.28 g/mol
Synonyms	8,2'-Ethano-2'-deoxyadenosine; 8,2'-Cyclo-2'-deoxyadenosine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-8,2'-ethano-1H-imidazo[2,1-i]purine; 8,2'-Anhydro-8-mercapto-2'-deoxyadenosine derivative; Bridged 2'-Deoxyadenosine analog; 8,2'-Methano-2'-deoxyadenosine (related); Ethano-bridged nucleoside
EINECS	Contact for details

Quality Control

Every batch of 8,2'-Ethano-Cyclo-2'-Deoxyadenosine is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.