Description

3'-Bromo-3'-Deoxythymidine is a halogenated nucleoside analog, a crucial building block in medicinal chemistry and biochemical research. This compound serves as a versatile intermediate for the synthesis of modified oligonucleotides and potential antiviral or anticancer agents. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity, reliable chemical intermediates for advanced development projects.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Oligonucleotide Synthesis: Used to incorporate bromine-modified thymidine into DNA/RNA strands for structural studies and probe development.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving DNA polymerases and related enzymes.
• Prodrug Development: Utilized in the design and synthesis of prodrugs to enhance drug delivery and efficacy.
• Diagnostic Reagent Manufacturing: Acts as a raw material for producing labeled nucleotides used in diagnostic assays and kits.
• Academic & Industrial R&D: Fundamental reagent for investigating nucleic acid chemistry, metabolism, and drug mechanisms of action.

Basic Information

Product Name	3'-Bromo-3'-Deoxythymidine
CAS No.	99785-51-0
Molecular Formula	C10H13BrN2O5
Molecular Weight	321.13 g/mol
Synonyms	3'-Bromo-3'-deoxythymidine; 1-[(2R,4S,5R)-4-Bromo-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3'-Bromo-2',3'-dideoxythymidine; BrdUrd (ambiguous, often refers to 5-Bromo-2'-deoxyuridine); 3'-Bromo-ddT; Thymidine, 3'-bromo-3'-deoxy-; 3’-Bromo-3’-deoxythymidine
EINECS	Contact for details

Quality Control

Our 3'-Bromo-3'-Deoxythymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.