Description

8-Azidoguanosine Cyclic Monophosphate is a chemically modified nucleotide analog designed for advanced biochemical research and pharmaceutical development. This compound is particularly valuable for its photoreactive azido group, which enables site-specific crosslinking and labeling studies in complex biological systems. It is primarily utilized by researchers and manufacturers in the fields of nucleotide chemistry, photaffinity labeling, and proteomics to investigate enzyme mechanisms, protein-nucleic acid interactions, and signal transduction pathways.

Application

• Photaffinity Labeling Probe: Acts as a critical tool for identifying and characterizing nucleotide-binding sites on proteins and enzymes.
• Biochemical Research Reagent: Used in studies of cyclic nucleotide signaling, particularly involving cGMP-dependent pathways.
• Proteomics and Target Identification: Facilitates the discovery of novel drug targets by covalently tagging interacting biomolecules upon UV irradiation.
• Enzyme Mechanism Studies: Employed to elucidate the structure and function of guanylyl cyclases and phosphodiesterases.
• Molecular Biology Tool: Serves as a substrate analog for investigating nucleic acid metabolism and repair mechanisms.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutics targeting nucleotide-related processes.

Basic Information

Product Name	8-Azidoguanosine Cyclic Monophosphate
CAS No.	99754-65-1
Molecular Formula	C10H11N8O7P
Molecular Weight	386.22 g/mol
Synonyms	8-Azido-cGMP; 8-Azidoguanosine 3',5'-cyclic monophosphate; 8-N3-cGMP; 8-Azido-cyclic GMP; Guanosine, 8-azido-, 3',5'-(hydrogen phosphate); cGMP, 8-azido-; 8-Azidoguanosine 3',5'-cyclic phosphate
EINECS	Contact for details

Quality Control

Our 8-Azidoguanosine Cyclic Monophosphate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, with specifications available to meet the requirements of academic, biotech, and pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the container to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.