Description

(E)-5-(2-Carboxyvinyl)Uridine is a modified nucleoside derivative, a key building block in organic synthesis and biochemical research. This compound is valued for its role as a versatile intermediate in the development of novel pharmaceuticals, particularly antiviral and anticancer agents, as well as in the synthesis of modified oligonucleotides. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry and drug discovery programs. The product is supplied with a high level of purity and consistency to meet the stringent requirements of advanced synthetic applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways involving pyrimidine nucleotides.
• Oligonucleotide Synthesis: Serves as a modified monomer for incorporating specific functionalities into synthetic DNA or RNA strands for therapeutic and diagnostic applications.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and selectivity.
• Probe Development: Utilized in the creation of labeled nucleosides for imaging, diagnostic assays, and molecular biology techniques.
• Academic & Industrial R&D: A fundamental reagent for exploring new chemical entities and reaction methodologies in nucleoside chemistry.

Basic Information

Product Name	(E)-5-(2-Carboxyvinyl)Uridine
CAS No.	99394-52-2
Molecular Formula	C12H14N2O8
Molecular Weight	314.25 g/mol
Synonyms	5-Carboxyvinyluridine; 5-[(1E)-2-Carboxyethenyl]uridine; (E)-5-(2-Carboxyethenyl)uridine; 5-(2-Carboxyvinyl)uridine; 5-Vinyluridine-2'-carboxylic acid; Uridine, 5-(2-carboxyethenyl)-, (E)-; 5-(trans-2-Carboxyvinyl)uridine
EINECS	Contact for details

Quality Control

Our (E)-5-(2-Carboxyvinyl)Uridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.