Description

Levodropropizine is the pharmacologically active (S)-enantiomer of dropropizine, functioning as a peripherally-acting antitussive agent. This compound is valued for its ability to suppress cough reflexes with a favorable side-effect profile, particularly a lower incidence of sedation compared to other agents. It is a critical active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of prescription and over-the-counter cough suppressants and syrups.

Application

• Pharmaceutical API: Primary use as the key active ingredient in antitussive (cough suppressant) medications.
• Prescription Cough Syrups: Formulation into liquid dosage forms for targeted, potent cough relief.
• Over-the-Counter (OTC) Medications: Incorporation into accessible cough drops, lozenges, and syrups.
• Pediatric Formulations: Development of cough relief products with a focus on improved tolerability for children.
• Combination Drug Therapies: Used in fixed-dose combinations with expectorants, antihistamines, or decongestants.
• Clinical Research: Serves as a reference standard and raw material for pharmacological studies and new drug development.

Basic Information

Product Name	Levodropropizine
CAS No.	99291-25-5
Molecular Formula	C13H20N2O2
Molecular Weight	236.31 g/mol
Synonyms	(S)-(-)-Dropropizine; (S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol; Levodropropizin; S(-)-Dropropizine; Dexdropropizine (Note: often used interchangeably but technically the (R)-enantiomer); L-Dropropizine; (-)-Dropropizine
EINECS	Contact for details

Quality Control

Our Levodropropizine is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with typical specifications covering identity, assay, enantiomeric purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with agreed specifications are available for every batch. Our quality commitment ensures reliability for your GMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The original container should be kept sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.