Description

Benzonatate is a non-narcotic antitussive agent, chemically classified as a peripherally-acting cough suppressant. Its primary value lies in its ability to effectively manage cough symptoms by anesthetizing the stretch receptors in the respiratory passages, without causing central nervous system depression. This product is essential for pharmaceutical manufacturers and research institutions developing formulations for dry, non-productive coughs associated with conditions like the common cold or bronchitis.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in prescription and over-the-counter (OTC) antitussive medications, including capsules and liquid formulations.
• Cough Suppressant Formulations: Formulation into various dosage forms such as soft gel capsules, lozenges, and pediatric syrups for targeted cough relief.
• Clinical Research & Development: Serves as a reference standard and raw material in pharmacokinetic, pharmacodynamic, and new drug delivery system studies.
• Generic Drug Manufacturing: Critical for companies producing generic versions of branded antitussive drugs containing Benzonatate.
• Veterinary Pharmaceuticals: Potential application in developing cough management solutions for veterinary use.

Basic Information

Product Name	Benzonatate
CAS No.	104-31-4
Molecular Formula	C30H53NO11
Molecular Weight	603.75 g/mol
Synonyms	2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl p-(butylamino)benzoate; Tessalon; Tessalon Perles; Pectussin; Ventussin; Benzononatine; Benzonatatum; Ethyl p-butylaminobenzoate 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl ester
EINECS	203-192-5

Quality Control

Our Benzonatate is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Specific Rotation	-18.0° to -22.0°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.