Description

Benproperine Phosphate is a pharmaceutical active ingredient primarily used as a potent non-narcotic antitussive agent. It matters for its selective action on the cough center in the medulla oblongata, effectively suppressing coughs without significant respiratory depression. This compound is essential for manufacturers in the global pharmaceutical industry developing and producing prescription and over-the-counter cough suppressant formulations.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in antitussive (cough suppressant) medications.
• Solid Dosage Forms: Formulation into tablets, capsules, and lozenges for oral administration.
• Liquid Formulations: Used in the production of syrups and oral solutions for pediatric and geriatric use.
• Combination Therapies: Incorporated into multi-ingredient cold and flu preparations alongside analgesics, antihistamines, or decongestants.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of benproperine phosphate-based medicines.
• Clinical Research: Serves as a reference standard and raw material in pharmacological studies and new drug development.

Basic Information

Product Name	Benproperine Phosphate
CAS No.	19428-14-9
Molecular Formula	C21H27NO • H3PO4
Molecular Weight	407.43 g/mol (for phosphate salt)
Synonyms	1-[1-Methyl-2-(2-phenylethoxy)ethyl]piperidine phosphate; Benproperine Phosphate; Benproperine Phosphate Salt; Blascorid; Pirexyl; Tussafug; Tussirama; 1-Methyl-2-(2-phenylethoxy)ethylpiperidine Phosphate
EINECS	243-096-8

Quality Control

Our Benproperine Phosphate is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with comprehensive testing including identification, assay, and impurity profiling. A Certificate of Analysis (COA) detailing specific results for each batch is provided to ensure traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.