Description

Dextromethorphan Hydrochloride CAS NO 18609-21-7 is the hydrochloride salt of dextromethorphan, a well-characterized pharmaceutical active ingredient. This compound is a critical component in the formulation of safe and effective antitussive (cough suppressant) medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of over-the-counter and prescription cough, cold, and flu remedies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key antitussive agent in solid dosage forms (tablets, capsules) and liquid formulations (syrups, solutions).
• Over-the-Counter (OTC) Medications: Formulation of non-prescription cough suppressants for adult and pediatric use.
• Prescription Drug Formulations: Used in combination with other APIs in prescription-strength cough and cold preparations.
• Research & Development (R&D): Serves as a reference standard and starting material in pharmacological research and new drug development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for generic and branded drug production.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for cough suppression in animals.

Basic Information

Product Name	Dextromethorphan Hydrochloride
CAS No.	18609-21-7
Molecular Formula	C18H25NO • HCl
Molecular Weight	307.86 g/mol
Synonyms	Dextromethorphan HBr (common alternative salt); DXM Hydrochloride; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan Hydrochloride; d-Methorphan Hydrochloride; Romilar Hydrochloride; NSC-83688; Dextromethorphan HCl; 1,2,3,9,10,10a-Hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethanophenanthrene Hydrochloride
EINECS	242-432-1

Quality Control

Our Dextromethorphan Hydrochloride is manufactured under strict quality systems. It undergoes rigorous analytical testing to ensure compliance with relevant pharmacopeial standards such as USP, EP, and BP. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.5% - 101.5% (on anhydrous basis)
Water (KF Titration)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%
Optical Rotation	+27° to +30° (c = 2 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.