Description

Oxolamine Dihydrogen Phosphate is a high-purity, pharmacologically active phosphate salt of the antitussive agent oxolamine. This compound is valued for its role as a key pharmaceutical intermediate in the synthesis of modern cough suppressants and respiratory therapeutics. It is primarily utilized by manufacturers in the pharmaceutical industry for the development of finished dosage forms, including syrups and tablets, requiring precise and reliable active pharmaceutical ingredient (API) sourcing.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of oxolamine-based antitussive (cough suppressant) APIs.
• Respiratory Therapeutics: Formulation into finished pharmaceutical products such as cough syrups, lozenges, and tablets.
• Clinical Research: Serves as a reference standard and raw material in pharmacological studies and drug development pipelines.
• GMP Manufacturing: Supplied to contract manufacturing organizations (CMOs) and in-house production facilities operating under Good Manufacturing Practices.
• Analytical Standard: Used in quality control laboratories for method development, validation, and calibration in HPLC and other analytical techniques.

Basic Information

Product Name	Oxolamine Dihydrogen Phosphate
CAS No.	1949-19-5
Molecular Formula	C₁₄H₁₉N₃O₅P
Molecular Weight	340.29 g/mol
Synonyms	Oxolamine Phosphate; Oxolamine Acid Phosphate; 2-(3,5-Dimethylphenoxymethyl)-2-imidazoline Dihydrogen Phosphate; Perebron; Bredon (as phosphate salt); Oxolaminium Dihydrogen Phosphate; Tussibron
EINECS	217-775-9

Quality Control

Our Oxolamine Dihydrogen Phosphate is manufactured and tested to meet stringent pharmaceutical-grade standards. Each batch is subjected to comprehensive analytical testing including identification, assay, and impurity profiling to ensure compliance with in-house specifications aligned with ICH guidelines. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and quality assurance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.