Description

Dextromethorphan Hydrobromide is a high-purity, non-opioid antitussive agent widely recognized for its efficacy in suppressing cough reflexes. This active pharmaceutical ingredient (API) is critical for formulators requiring a reliable and potent cough suppressant with a favorable safety profile. It is primarily utilized by pharmaceutical manufacturers in the production of over-the-counter (OTC) and prescription cough syrups, lozenges, and multi-symptom cold relief formulations.

Application

• Pharmaceutical API: Primary active ingredient in OTC and prescription antitussive (cough suppressant) medications.
• Cough Syrup Formulations: Used in liquid preparations for both adult and pediatric cough and cold remedies.
• Solid Dosage Forms: Incorporated into lozenges, chewable tablets, and gel capsules for convenient administration.
• Multi-Symptom Relief Products: Combined with analgesics, antihistamines, and decongestants in comprehensive cold and flu formulas.
• Veterinary Pharmaceuticals: Employed in certain veterinary cough preparations.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological and neurological research.

Basic Information

Product Name	Dextromethorphan Hydrobromide
CAS No.	125-69-9
Molecular Formula	C18H25NO • HBr
Molecular Weight	370.31 g/mol
Synonyms	Dextromethorphan HBr; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan Hydrobromide; DXM HBr; (+)-Dextromethorphan Hydrobromide; Dextromethorphan Hydrobromide Monohydrate; Dextromethorphan Bromhydrate; NSC-83653; Ro 1-5470/6
EINECS	204-752-5

Quality Control

Our Dextromethorphan Hydrobromide is manufactured under strict quality management systems. It is produced to meet exacting standards, including USP/EP/BP monographs where applicable, ensuring suitability for pharmaceutical applications. Every batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (on dried basis)	98.5% - 101.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	+27° to +30° (c = 2 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.