Description

Hydroxypropyl-γ-Cyclodextrin is a chemically modified cyclic oligosaccharide derived from γ-cyclodextrin, designed to enhance solubility and stability. This versatile excipient is crucial for improving the bioavailability and delivery of poorly soluble active pharmaceutical ingredients (APIs). It is essential for formulation scientists and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries seeking advanced drug delivery solutions.

Application

• Pharmaceutical Solubilization & Stabilization: Acts as a superior solubilizing and stabilizing agent for hydrophobic drugs in injectable, oral, and topical formulations.
• Drug Delivery Systems: Used in the development of inclusion complexes to enhance drug permeability, bioavailability, and targeted release.
• Biotechnology & Protein Formulation: Stabilizes proteins, peptides, and antibodies against aggregation and denaturation in biotherapeutic products.
• Cosmetics & Personal Care: Improves the solubility and skin penetration of active ingredients in creams, lotions, and serums.
• Food & Flavor Encapsulation: Encapsulates flavors, colors, and nutraceuticals to mask bitterness, control release, and improve stability.
• Analytical Chemistry: Serves as a chiral selector in capillary electrophoresis and HPLC for enantiomeric separation.
• Chemical Research: Utilized as a green chemistry catalyst and molecular host in supramolecular chemistry and nanotechnology applications.

Basic Information

Product Name	Hydroxypropyl-γ-Cyclodextrin
CAS No.	99241-25-5
Molecular Formula	(C48H80O40)n • (C3H6O)x
Molecular Weight	Variable (Molar Substitution Dependent)
Synonyms	HP-γ-CD; 2-Hydroxypropyl-γ-cyclodextrin; Hydroxypropyl Gamma Cyclodextrin; γ-Cyclodextrin, 2-hydroxypropyl ether; Heptakis(2-hydroxypropyl)-γ-cyclodextrin; Kleptose® HP-Gamma; Cavitron™ HP-γ-CD; Hydroxypropyl Gamma Cyclodextrin (HPGCD)
EINECS	Contact for details

Quality Control

Our Hydroxypropyl-γ-Cyclodextrin is manufactured under a strict quality management system. Each batch is tested to ensure compliance with relevant pharmaceutical and food-grade standards, including potential alignment with USP/NF, EP, and FCC monographs where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, substitution degree, and impurity profiles is provided with every shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect product performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-γ-CD Content)	≥ 98.0% (on dried basis)
Molar Substitution (MS)	0.4 - 1.0 (Typical, customizable)
Water Content (Karl Fischer)	≤ 10.0 %
Residue on Ignition (Sulfated Ash)	≤ 0.1 %
Heavy Metals (as Pb)	≤ 10 ppm
Microbial Enumeration Tests	Meets Ph. Eur./USP criteria
pH (10% Solution)	5.0 - 7.5
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.