Description

Cremophor EL is a non-ionic surfactant and solubilizer derived from castor oil and ethylene oxide. This versatile excipient is crucial for enhancing the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) in liquid formulations. It is an essential component for formulators in the pharmaceutical, cosmetic, and specialty chemical industries seeking reliable and effective solubilization.

Application

• Pharmaceutical Solubilizer: Primary use in oral, topical, and injectable formulations to dissolve lipophilic drugs.
• Vitamin & Supplement Formulations: Used in fat-soluble vitamin (A, D, E, K) preparations for improved absorption.
• Cosmetic & Personal Care: Acts as an emulsifier and solubilizer in creams, lotions, and fragrances.
• Agricultural Formulations: Employed as an emulsifier and wetting agent in pesticide and herbicide concentrates.
• Industrial Applications: Used in textile processing, leather treatment, and as a dye leveling agent.
• Research & Development: A standard solubilizing agent in preclinical and clinical trial formulations.

Basic Information

Product Name	Cremophor EL
CAS No.	61791-12-6
Molecular Formula	Contact for details
Molecular Weight	~2,500 g/mol (Typical)
Synonyms	Polyoxyl 35 Castor Oil; PEG-35 Castor Oil; Macrogolglyceroli ricinoleas 35; Kolliphor EL; Ethoxylated Castor Oil; Polyoxyethylene (35) Castor Oil; Oxirane, methyl-, polymer with 1,2,3-propanetriol tri(9Z)-9-octadecenoate (35 mol EO average molar ratio)
EINECS	263-125-1

Quality Control

Our Cremophor EL is manufactured and tested to meet high-purity standards suitable for demanding applications. We provide comprehensive quality assurance, with production potentially aligned to in-house pharmacopeial standards (e.g., USP/NF, Ph. Eur.). A detailed Certificate of Analysis (COA) is available for each batch, confirming identity, purity, and key physicochemical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Pale yellow to yellow viscous liquid
Identification (IR)	Conforms
Hydroxyl Value	65 - 78 mg KOH/g
Saponification Value	65 - 70 mg KOH/g
Acid Value	≤ 2.0 mg KOH/g
Water Content (KF)	≤ 2.0 %
Peroxide Value	≤ 5.0 mEq/kg
Ethylene Oxide & Dioxan	Meet applicable limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.