Description

Gelucire 44-14 is a semi-solid, non-ionic surfactant and lipid excipient derived from polyglycolized glycerides. This versatile compound is highly valued for its solubilizing and self-emulsifying properties, which enhance the bioavailability of poorly water-soluble active pharmaceutical ingredients. It is a critical material for formulation scientists in the pharmaceutical and nutraceutical industries, particularly for developing oral solid dosage forms and lipid-based drug delivery systems. Gelucire 44-14 CAS NO 121548-04-7 offers a unique balance of hydrophilic and lipophilic characteristics.

Application

• Pharmaceutical Formulations: Primarily used as a solubilizer and bioavailability enhancer in solid dispersions for oral drugs with low aqueous solubility.
• Lipid-Based Drug Delivery Systems: A key component in self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS).
• Controlled Release Matrices: Employed in the manufacture of sustained-release tablets and capsules due to its melting and solidification properties.
• Nutraceutical & Cosmetic Products: Used to improve the delivery and stability of fat-soluble vitamins and active cosmetic ingredients.
• Hot Melt Coating & Granulation: Serves as a binder and coating agent in melt granulation and coating processes for multiparticulate systems.

Basic Information

Product Name	Gelucire 44-14
CAS No.	121548-04-7
Molecular Formula	Mixture of polyglycolized glycerides
Molecular Weight	N/A (Mixture)
Synonyms	Gelucire 44/14; Polyglycolized Glycerides, Type 44/14; Lauroyl Polyoxyl-32 Glycerides; PEG-32 Glyceryl Laurate; Gattefossé Gelucire 44/14; Glyceryl Laurate Polyethylene Glycol 1500 Ester; Excipient Gelucire 44-14
EINECS	Contact for details

Quality Control

Our Gelucire 44-14 is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) that includes critical parameters such as acid value, hydroxyl value, saponification value, and melting point. We ensure compliance with relevant pharmacopeial guidelines (where applicable) and industry best practices for excipient quality. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can alter its physical properties.

Specification

Item	Specification
Description	White to off-white waxy solid
Identification (IR)	Conforms
Melting Point	43 - 47 °C
Acid Value	≤ 2.0 mg KOH/g
Hydroxyl Value	30 - 40 mg KOH/g
Saponification Value	95 - 115 mg KOH/g
Heavy Metals	≤ 10 ppm
Water Content	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.