Description

4-Chloro-2-(Trifluoromethyl)Phenyl Isothiocyanate is a versatile and highly reactive aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethyl and chloro substituents, which significantly influence its reactivity and the properties of downstream compounds. This intermediate is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Pharmaceutical Building Block: Used in medicinal chemistry for constructing heterocyclic scaffolds and bioactive molecules, including potential kinase inhibitors and antimicrobial agents.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Polymer Modification: Acts as a functional monomer or cross-linking agent to introduce specific properties into advanced polymer systems.
• Dye and Pigment Chemistry: Serves as an intermediate in the production of specialized dyes and functional colorants.
• Chemical Research & Development: A valuable reagent for exploring new synthetic pathways and creating compound libraries for high-throughput screening.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)Phenyl Isothiocyanate
CAS No.	99195-86-5
Molecular Formula	C8H3ClF3NS
Molecular Weight	237.63 g/mol
Synonyms	1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene; 4-Chloro-α,α,α-trifluoro-o-tolyl isothiocyanate; 2-(Trifluoromethyl)-4-chlorophenyl isothiocyanate; 4-Chloro-2-trifluoromethylphenyl isothiocyanate; NSC 405124; 4-Chloro-α,α,α-trifluoro-2-tolyl isothiocyanate; 2-Trifluoromethyl-4-chlorophenyl isothiocyanate
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)Phenyl Isothiocyanate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.