Description

2-Bromo-1-(4-Ethynylphenyl)Ethanone is a versatile and highly functionalized organic building block, featuring both a reactive bromoacetyl group and an ethynyl (acetylene) moiety. This unique bifunctional structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or other therapeutic areas requiring complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced polymers, conductive materials, or metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Utilized for creating tagged molecules or affinity probes due to its reactive handles for click chemistry (via the alkyne) and further functionalization (via the bromo group).
• Organic Synthesis Research: A valuable reagent in academic and industrial labs for exploring new palladium-catalyzed cross-coupling reactions (e.g., Sonogashira) and other C-C bond-forming transformations.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine or N-heterocyclic carbene (NHC) ligands for asymmetric catalysis.

Basic Information

Product Name	2-Bromo-1-(4-Ethynylphenyl)Ethanone
CAS No.	98993-86-3
Molecular Formula	C10H7BrO
Molecular Weight	223.07 g/mol
Synonyms	2-Bromo-1-(4-ethynylphenyl)ethan-1-one; 4-Ethynylphenacyl Bromide; 2-Bromo-4'-ethynylacetophenone; 1-(4-Ethynylphenyl)-2-bromoethanone; α-Bromo-4-ethynylacetophenone; p-Ethynylphenacyl Bromide; 98993-86-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4-Ethynylphenyl)Ethanone is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.