Description

3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)-2'-Deoxyuridine is a high-purity, protected nucleoside derivative essential for advanced oligonucleotide synthesis. This compound is a critical building block for the automated solid-phase synthesis of DNA and RNA sequences, where it provides precise protection for the 3' and 5' hydroxyl groups. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions developing therapeutic oligonucleotides, diagnostic probes, and primers. The CAS number for this compound is 98495-56-8.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated synthesis of DNA and RNA strands in antisense, siRNA, and aptamer development.
• Pharmaceutical Research: Used in the discovery and production of novel oligonucleotide-based therapeutics targeting genetic diseases, cancers, and viral infections.
• Molecular Diagnostics: Serves as a building block for manufacturing labeled probes and primers used in PCR, sequencing, and microarray technologies.
• Bioconjugation & Labeling: Enables the site-specific introduction of modifications, fluorophores, or other functional groups into nucleic acid constructs.
• Academic & Contract Research: Supports fundamental research in molecular biology, biochemistry, and genetics requiring custom oligonucleotides.
• Process Development: Employed in scaling up GMP-grade manufacturing processes for clinical and commercial-stage oligonucleotide drugs.

Basic Information

Product Name	3',5'-o-(1,1,3,3-Tetraisopropyl-1,3-Disiloxanediyl)-2'-Deoxyuridine
CAS No.	98495-56-8
Molecular Formula	C22H40N2O6Si2
Molecular Weight	484.74 g/mol
Synonyms	2'-Deoxyuridine, 3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 2'-Deoxyuridine, 3',5'-bis-O-(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-Di-O-(tert-butyldimethylsilyl)-2'-deoxyuridine (common error/related compound); 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine; TIPDS-dU; TIPDS-protected deoxyuridine; 5-Methyluridine 3',5'-cyclic TIPDS ether; dU TIPDS ether
EINECS	Contact for details

Quality Control

Our 3',5'-o-(1,1,3,3-Tetraisoxanediyl)-2'-Deoxyuridine is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive oligonucleotide synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.