Description

Cyclopropanecarbonyl Chloride, 1,2,2-Trimethyl- (6Ci) is a specialized organic acid chloride derivative of a trimethylcyclopropane structure, serving as a critical building block in advanced organic synthesis. Its value lies in its highly reactive carbonyl chloride group, which enables efficient acylation reactions to introduce the sterically hindered and conformationally unique cyclopropane moiety into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, where the cyclopropane ring is prized for its ability to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of active pharmaceutical ingredients (APIs), particularly those incorporating a sterically constrained cyclopropane scaffold to enhance potency and selectivity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trimethylcyclopropane group can improve environmental stability and target specificity.
• Material Science Research: Employed as a monomer or cross-linking agent in the synthesis of specialty polymers with unique thermal and mechanical properties derived from the rigid cyclopropane ring.
• Ligand and Catalyst Development: Serves as a starting material for creating chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the three-dimensional structure for stereocontrol.
• Fine Chemical Production: Integral in the multi-step synthesis of complex fragrance compounds, flavors, and other high-value specialty chemicals.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 1,2,2-Trimethyl- (6Ci)
CAS No.	98431-01-7
Molecular Formula	C7H11ClO
Molecular Weight	146.62 g/mol
Synonyms	1,2,2-Trimethylcyclopropanecarbonyl Chloride; Trimethylcyclopropanecarbonyl Chloride; 1,2,2-Trimethylcyclopropanecarboxylic Acid Chloride; (1,2,2-Trimethylcyclopropyl)carbonyl Chloride; Cyclopropanecarboxylic Acid, 1,2,2-Trimethyl-, Chloride; 98431-01-7
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarbonyl Chloride, 1,2,2-Trimethyl- (6Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including purity assay and identification of key impurities. A Certificate of Analysis (COA) detailing specifications such as purity (by GC or HPLC), identity (by IR and/or NMR), and acid chloride content is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.