Description

4-Methoxy-2-(trifluoromethyl)benzoyl chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the trifluoromethyl and methoxy substituents, which are key motifs for modulating the lipophilicity, metabolic stability, and electronic properties of target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring fine-tuned biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing specialized aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or modifying agent for creating high-performance polymers with specific thermal and chemical resistance properties.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of complex dyes and pigments, contributing to color fastness and stability.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new chemical entities and reaction pathways.

Basic Information

Item	Details
Product Name	4-Methoxy-2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	98187-17-8
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	4-Methoxy-2-(trifluoromethyl)benzoyl chloride; 2-Trifluoromethyl-4-methoxybenzoyl chloride; 4-Methoxy-α,α,α-trifluoro-o-toluoyl chloride; 98187-17-8; p-Methoxy-α,α,α-trifluoro-o-toluic acid chloride; o-Toluoyl chloride, 4-methoxy-α,α,α-trifluoro-; Benzoyl chloride, 4-methoxy-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 4-Methoxy-2-(trifluoromethyl)benzoyl chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the exacting standards required for pharmaceutical and agrochemical applications. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity limits is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.