Description

4-Chloro-2-Trifluoromethylbenzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the trifluoromethyl and chloro substituents, which impart unique electronic and steric properties essential for modifying the biological activity and physical characteristics of target molecules. This intermediate is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D sectors for the production of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a benzoyl moiety with halogen and fluorine substitution for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in manufacturing herbicides, fungicides, and insecticides where the trifluoromethyl group is a critical pharmacophore for efficacy.
• Liquid Crystal & OLED Material Production: Serves as a building block for creating advanced functional materials used in displays and electronics.
• Polymer Modification: Employed to introduce functional side chains into polymers, altering their chemical resistance and physical properties.
• Dyestuff and Pigment Intermediate: Utilized in the synthesis of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed reactions like Suzuki or Stille couplings for constructing biaryl systems.
• Peptide Mimetics & PROTACs: Used in medicinal chemistry for constructing peptide-like structures and proteolysis-targeting chimeras (PROTACs).

Basic Information

Product Name	4-Chloro-2-Trifluoromethylbenzoyl Chloride
CAS No.	98187-13-4
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	2-Trifluoromethyl-4-chlorobenzoyl chloride; 4-Chloro-α,α,α-trifluoro-o-toluoyl chloride; 4-Chloro-2-(trifluoromethyl)benzoyl chloride; 4-Chloro-α,α,α-trifluoro-2-methylbenzoyl chloride; Benzoyl chloride, 4-chloro-2-(trifluoromethyl)-; o-Trifluoromethyl-p-chlorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Trifluoromethylbenzoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and amines. Due to its reactivity as an acid chloride and sensitivity to moisture, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Typical storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.