Description

5'-O-(Dimethoxytrityl)-N6-Methyl-2'-Deoxyadenosine is a high-purity, protected nucleoside derivative essential for the solid-phase synthesis of oligonucleotides. This compound is critical for researchers and manufacturers requiring precise control over nucleic acid sequences, particularly for introducing specific methylation patterns. It is primarily used in the development of therapeutic oligonucleotides, diagnostic probes, and advanced research tools within the pharmaceutical, biotechnology, and life sciences sectors.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated solid-phase synthesis of DNA strands containing N6-methyladenosine (m6A) modifications.
• Therapeutic Development: Used in the research and production of antisense oligonucleotides (ASOs), siRNA, and aptamers for targeted therapies.
• Diagnostic Probes: Manufacture of labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and microarray analysis.
• Epigenetics Research: Essential reagent for studying the role and function of m6A modifications in RNA and DNA, a key area in epigenetics.
• Bioconjugation: Serves as a building block for creating nucleotide conjugates used in drug delivery and biomarker studies.
• Process Development: Employed in scaling up GMP-grade oligonucleotide manufacturing for clinical trial materials and commercial products.

Basic Information

Product Name	5'-O-(Dimethoxytrityl)-N6-Methyl-2'-Deoxyadenosine
CAS No.	98056-69-0
Molecular Formula	C32H33N5O5
Molecular Weight	567.64 g/mol
Synonyms	N6-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine; DMTr-N6-Me-dA; 5'-O-DMT-N6-methyl-2'-deoxyadenosine; N6-Methyl-2'-deoxyadenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl] derivative; 2'-Deoxy-N6-methyladenosine 5'-(4,4'-dimethoxytrityl) ether; N6-Methyl-5'-O-DMT-deoxyadenosine; Protected N6-Methyl-deoxyadenosine; m6dA(DMT)
EINECS	Contact for details

Quality Control

Our 5'-O-(Dimethoxytrityl)-N6-Methyl-2'-Deoxyadenosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to industry best practices and can support development under GMP guidelines for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
DMTr Content	95 - 102%
Solubility	Soluble in acetonitrile, DMF, pyridine

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.