Description

Oxolan-3-Yl Chloroformate is a versatile and highly reactive chloroformate ester derivative of tetrahydrofuran. This compound is a critical building block in organic synthesis, primarily valued for its role as a carboxylating and protecting group agent. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise intermediates for constructing complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the oxolan-3-yloxycarbonyl protecting group.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where specific ester functionalities are required.
• Polymer Chemistry: Acts as a monomer or modifying agent in the synthesis of specialized polycarbonates and other functional polymers.
• Peptide & Protein Research: Employed as a carboxylating agent for modifying amino acids or for temporary protection of functional groups during solid-phase peptide synthesis.
• Material Science: Utilized in surface modification and the creation of novel organic frameworks and coatings.
• Chemical Research & Development: Serves as a fundamental reagent for exploring new synthetic methodologies and creating novel chemical entities in R&D laboratories.

Basic Information

Product Name	Oxolan-3-Yl Chloroformate
CAS No.	98021-98-8
Molecular Formula	C5H7ClO3
Molecular Weight	150.56 g/mol
Synonyms	3-Tetrahydrofuranyl Chloroformate; Tetrahydrofuran-3-yl Chloroformate; 3-Oxolanyl Chloroformate; Chloroformic Acid 3-Tetrahydrofuranyl Ester; Oxolan-3-yl Carbonochloridate; THF-3-yl Chloroformate; 3-THF Chloroformate
EINECS	Contact for details

Quality Control

Our Oxolan-3-Yl Chloroformate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to relevant industry standards and can support development projects requiring specific analytical methodologies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.