Description

5-Hydroxypropyl-2'-Deoxyuridine is a modified nucleoside analog of deoxyuridine, featuring a hydroxypropyl substitution at the 5-position of the uracil ring. This structural modification is critical for its role as a biochemical tool in nucleic acid research, particularly in studying DNA synthesis, repair mechanisms, and enzyme interactions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in antiviral and anticancer drug discovery, as well as molecular biology applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to thymidylate synthase and other nucleotide-metabolizing enzymes.
• Antiviral Drug Development: Serves as a key intermediate or analog in the research and synthesis of novel nucleoside-based antiviral agents.
• Molecular Biology Probes: Incorporated into oligonucleotides to study DNA structure, function, and protein-DNA interactions.
• Cancer Research: Investigated for its potential effects on cell proliferation and as a tool in studying chemotherapeutic mechanisms.
• Diagnostic Reagent Synthesis: Acts as a building block for labeled nucleotides used in diagnostic assays and sequencing.

Basic Information

Product Name	5-Hydroxypropyl-2'-Deoxyuridine
CAS No.	97974-98-6
Molecular Formula	C12H18N2O6
Molecular Weight	286.28 g/mol
Synonyms	5-(2-Hydroxypropyl)-2'-deoxyuridine; 5-HPDU; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(2-hydroxypropyl)pyrimidine-2,4(1H,3H)-dione; 5-(2-Hydroxypropyl)deoxyuridine; 2'-Deoxy-5-(2-hydroxypropyl)uridine; 5-(2-Hydroxypropyl)-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Hydroxypropyl-2'-Deoxyuridine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.