Description

Methotrexate-γ-1,2-Dimyristoylphosphatidylethanolamine is a specialized phospholipid conjugate of the chemotherapeutic agent methotrexate. This compound is engineered to enhance drug delivery and targeting, leveraging the properties of the lipid moiety to improve pharmacokinetics and cellular uptake. It is a critical intermediate and research material for pharmaceutical scientists and formulation developers working on advanced drug delivery systems, particularly in oncology and targeted therapy applications.

Application

• Research and development of targeted liposomal drug delivery systems for cancer therapeutics.
• Key intermediate in the synthesis of phospholipid-drug conjugates for enhanced therapeutic efficacy.
• Formulation component for nanoparticle-based therapeutics to improve drug solubility and stability.
• Model compound in pharmacokinetic and biodistribution studies of lipid-conjugated drugs.
• Production of specialized reference standards for analytical method development in pharmaceutical QC.
• Investigational material for studying receptor-mediated endocytosis and intracellular drug release mechanisms.

Basic Information

Product Name	Methotrexate-γ-1,2-Dimyristoylphosphatidylethanolamine
CAS No.	97866-97-2
Molecular Formula	C61H99N9O13P
Molecular Weight	1197.45 g/mol
Synonyms	MTX-DMPE; Methotrexate-DMPE; Methotrexate-γ-DMPE; 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methotrexate-γ-amido(hexanoate)]; N-(Methotrexate-γ-hexanoyl)-1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine; Phospholipid-Methotrexate Conjugate; Lipid-MTX Conjugate; DMPE-Methotrexate
EINECS	Contact for details

Quality Control

Our Methotrexate-γ-1,2-Dimyristoylphosphatidylethanolamine is produced under strict quality management systems suitable for research and pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing batch-specific results. Our commitment to quality ensures material consistency for your critical formulation and preclinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to yellow solid or film
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	≤ 5.0% total
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.