Description

2'-Azido-2'-Deoxy-5-Methyluridine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its unique azido functionality makes it a versatile intermediate for click chemistry applications, enabling the synthesis of complex biomolecular probes and potential therapeutic agents. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing novel antiviral and anticancer nucleoside analogs, as well as for advanced oligonucleotide synthesis.

Application

• Medicinal Chemistry Intermediate: A crucial precursor for the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Click Chemistry Reagent: The azido group enables efficient, bioorthogonal conjugation (e.g., with alkynes) for labeling biomolecules, creating probes, and developing targeted therapies.
• Oligonucleotide Synthesis: Used in the solid-phase synthesis of modified DNA/RNA strands for antisense, siRNA, and aptamer research.
• Bioconjugation & Probe Development: Facilitates the attachment of fluorophores, affinity tags, or other functional groups to nucleosides for diagnostic and imaging applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA/RNA processing.
• Library Synthesis for Drug Discovery: Used in combinatorial chemistry to generate diverse libraries of nucleoside analogs for high-throughput screening.

Basic Information

Product Name	2'-Azido-2'-Deoxy-5-Methyluridine
CAS No.	97748-75-9
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	5-Methyl-2'-azido-2'-deoxyuridine; 2'-Azido-5-methyl-2'-deoxyuridine; 2'-N3-5-Me-dU; Azidothymidine analog; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Azido-2'-deoxythymidine (common misnomer); AZT-M derivative; N3-Azido nucleoside precursor
EINECS	Contact for details

Quality Control

Our 2'-Azido-2'-Deoxy-5-Methyluridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While typically supplied as a research-grade material, production can be aligned with cGMP guidelines for advanced pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.