Description

Carbocyclic Guanosine Monophosphate is a synthetic nucleoside analog where the ribose sugar moiety is replaced by a cyclopentane ring, offering enhanced metabolic stability. This structural modification makes it a valuable intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications in antiviral drug discovery, molecular biology, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a stable analog of natural guanosine monophosphate (GMP) to study enzyme kinetics and nucleotide metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Molecular Biology: Potential use in the study of nucleic acid interactions and the development of stable oligonucleotide probes.
• Enzyme Inhibitor Studies: Investigated for its activity against viral polymerases and other nucleotide-binding enzymes.

Basic Information

Product Name	Carbocyclic Guanosine Monophosphate
CAS No.	97727-47-4
Molecular Formula	C11H14N5O7P
Molecular Weight	359.23 g/mol
Synonyms	Carbocyclic GMP; c-GMP (carbocyclic); 9-[(1S,2R,3S)-2,3-Dihydroxy-4-methylenecyclopentyl]guanine 5'-(dihydrogen phosphate); Carba-GMP; Cyclopentyl GMP; Abacavir phosphate related compound; Acyclic nucleoside phosphonate precursor
EINECS	Contact for details

Quality Control

Our Carbocyclic Guanosine Monophosphate is manufactured under a quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.