Description

1-[2-Deoxy-3,5-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)-β-D-Ribofuranosyl]Thymine is a sophisticated nucleoside derivative, specifically a protected thymidine analog, where the 3' and 5' hydroxyl groups are shielded by a tetraisopropyldisiloxane (TIPS) group. This compound is critically important as a key protected intermediate in the automated synthesis of oligonucleotides, enabling the precise construction of DNA and RNA sequences. It is primarily needed by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors for developing therapeutics, probes, and primers.

Application

• Solid-Phase Oligonucleotide Synthesis: As a crucial phosphoramidite building block for the automated production of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) Development: For the research and manufacturing of therapeutic oligonucleotides targeting genetic diseases.
• siRNA and miRNA Synthesis: Used in the preparation of short interfering RNA and microRNA for gene silencing applications.
• PCR Primer and Probe Manufacturing: Enables the production of high-purity primers and labeled probes for molecular diagnostics.
• Research Scale Nucleic Acid Chemistry: Serves as a protected monomer for custom oligonucleotide synthesis in academic and industrial R&D labs.
• Synthesis of Modified Nucleosides: Acts as a starting material or intermediate for creating nucleoside analogs with tailored properties.

Basic Information

Product Name	1-[2-Deoxy-3,5-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)-β-D-Ribofuranosyl]Thymine
CAS No.	97626-18-1
Molecular Formula	C27H48N2O6Si2
Molecular Weight	552.86 g/mol
Synonyms	3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)thymidine; 5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)thymidine; TIPS-Thymidine; 1-[2-Deoxy-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-5-methyluracil; Thymidine 3',5'-bis(tetraisopropyldisiloxane) derivative; NSC 339586; Protected Thymidine Monomer
EINECS	Contact for details

Quality Control

Our 1-[2-Deoxy-3,5-o-(1,1,3,3-Tetraisopropyldisiloxane-1,3-Diyl)-β-D-Ribofuranosyl]Thymine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for sensitive oligonucleotide synthesis. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee batch-to-batch consistency and suitability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.