Description

Merbarone is a synthetic organic compound of significant interest in biochemical and pharmaceutical research. Its primary value lies in its well-characterized activity as a selective inhibitor of topoisomerase II, a critical enzyme involved in DNA replication and cell division. This makes it a valuable research tool for scientists in oncology and molecular biology, particularly for studying cell cycle mechanisms and developing novel therapeutic strategies. The compound is supplied as a high-purity material suitable for laboratory and research applications.

Application

• Biochemical Research: Used as a specific inhibitor of topoisomerase II in enzymatic assays and mechanistic studies.
• Oncology Research: Employed in in vitro and cell-based studies to investigate apoptosis, cell cycle arrest, and the mechanisms of anti-cancer drugs.
• Molecular Biology: A tool compound for probing DNA topology, replication, and repair processes in experimental models.
• Pharmacology: Used in preclinical research to evaluate the efficacy and selectivity of potential chemotherapeutic agents.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Merbarone
CAS No.	97534-21-9
Molecular Formula	C₁₃H₁₄N₂O₄
Molecular Weight	262.26 g/mol
Synonyms	5-(Phenylamino)-2-thiobarbituric acid; NSC 336628; 5-Anilino-2-thiobarbituric acid; 5-(Phenylamino)-2-sulfanylidene-1,3-diazinane-4,6-dione; Merbaron; Topoisomerase II inhibitor NSC 336628
EINECS	Contact for details

Quality Control

Our Merbarone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all test results and specifications is provided to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.