Description

(Chlorocarbonyldifluoromethyl)Phosphonic Acid Diethyl Ester is a specialized organophosphorus compound that serves as a critical building block in advanced chemical synthesis. Its unique molecular architecture, featuring both phosphonic ester and difluoromethyl carbonyl chloride functionalities, makes it a versatile reagent for introducing phosphonate and fluorinated groups into target molecules. This high-value intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting enzyme inhibition where the phosphonate moiety acts as a bioisostere.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, insecticides, and plant growth regulators, leveraging its fluorinated phosphonate structure.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of flame retardants, surface modifiers, and specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to develop activity-based probes and inhibitors for studying phosphonate-metabolizing enzymes.

Basic Information

Product Name	(Chlorocarbonyldifluoromethyl)Phosphonic Acid Diethyl Ester
CAS No.	97480-49-4
Molecular Formula	C6H10ClF2O4P
Molecular Weight	250.57 g/mol
Synonyms	Diethyl (Chlorocarbonyl)difluoromethylphosphonate; Diethyl (Chlorodifluoroacetyl)phosphonate; (Chlorodifluoroacetyl)phosphonic Acid Diethyl Ester; Phosphonic Acid, P-[(Chlorocarbonyl)difluoromethyl]-, Diethyl Ester; Diethyl Chlorodifluoromethylphosphonoformate
EINECS	Contact for details

Quality Control

Our production of (Chlorocarbonyldifluoromethyl)Phosphonic Acid Diethyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. We employ advanced analytical techniques including NMR, HPLC, and GC for identity confirmation and purity verification. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Ensure containers are kept tightly sealed to prevent moisture ingress and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.