Description

Di[Tris(Hydroxymethyl)Aminomethane] Phosphate is a high-purity, organically modified phosphate salt derived from the widely used biological buffer, Tris. This compound matters for its unique ability to provide buffering capacity in conjunction with phosphate functionality, making it valuable for specialized biochemical and industrial processes. It is primarily needed by manufacturers in the life sciences, pharmaceutical intermediates, and specialty chemical synthesis sectors where precise pH control and specific ionic properties are critical.

Application

• Biochemical Research & Diagnostics: Used as a specialized buffer component in enzyme assays, cell culture media, and diagnostic kit formulations requiring a combined Tris-phosphate buffer system.
• Pharmaceutical Intermediates: Serves as a key building block or buffering agent in the synthesis of certain active pharmaceutical ingredients (APIs) and nucleotide analogs.
• Molecular Biology: Employed in nucleic acid purification and electrophoresis protocols where its specific ionic characteristics can improve yield or resolution.
• Chromatography: Acts as a mobile phase modifier or buffer in High-Performance Liquid Chromatography (HPLC) for the separation of biomolecules.
• Specialty Chemical Synthesis: Utilized as a phosphorylating agent or catalyst in organic synthesis reactions for producing fine chemicals.
• Cosmetic & Personal Care: Can function as a pH stabilizer and conditioning agent in high-end cosmetic formulations.

Basic Information

Product Name	Di[Tris(Hydroxymethyl)Aminomethane] Phosphate
CAS No.	108321-11-5
Molecular Formula	C8H23N2O10P
Molecular Weight	338.25 g/mol
Synonyms	Bis-Tris Phosphate; Di-Tris Phosphate; 2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol phosphate (1:?); Tris Phosphate Dimer; THAM Phosphate Dimer; Bis(2-amino-2-(hydroxymethyl)-1,3-propanediol) phosphate; Phosphoric acid compound with tris(hydroxymethyl)aminomethane (2:1)
EINECS	Contact for details

Quality Control

Our Di[Tris(Hydroxymethyl)Aminomethane] Phosphate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay, impurity profile, and physical characteristics. While produced to high standards, this product is typically for research and industrial use; specific compendial standards (e.g., USP, EP) can be discussed for custom projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect quality and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
pH (1% Solution)	6.0 - 8.0
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.