Description

(Diethoxyphosphoryl)difluoroacetic acid is a specialized organophosphorus compound that serves as a versatile building block in advanced chemical synthesis. Its unique structure, combining a phosphonate ester with a difluoroacetic acid moiety, makes it a critical intermediate for introducing fluorine and phosphorus-containing functional groups. This high-value reagent is primarily needed by research institutions and industrial R&D teams working in pharmaceutical development, agrochemical discovery, and materials science, where it enables the creation of novel molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated phosphonate groups for enhanced metabolic stability or biological activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, insecticides, and plant growth regulators, leveraging its fluorine and phosphorus chemistry.
• Ligand and Catalyst Precursor: Serves as a starting material for creating specialized organophosphorus ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of flame retardants, specialty polymers, and surface-modifying agents due to its reactive functional groups.
• Chemical Biology Probe Development: Utilized to create mechanism-based inhibitors and activity-based probes for studying enzyme function, particularly phosphatases and kinases.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on incorporating difluoromethylene (CF2) and phosphonate units into complex molecular architectures.

Basic Information

Product Name	(Diethoxyphosphoryl)difluoroacetic Acid
CAS No.	97480-37-0
Molecular Formula	C6H11F2O5P
Molecular Weight	232.12 g/mol
Synonyms	Diethyl (Difluoroacetoxy)phosphonate; (Difluoroacetoxy)phosphonic Acid Diethyl Ester; Diethoxyphosphinyl Difluoroacetate; 2,2-Difluoro-2-(diethoxyphosphoryl)acetic Acid; Acetic Acid, 2-(Diethoxyphosphinyl)-2,2-difluoro-; Phosphono(difluoro)acetic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our (Diethoxyphosphoryl)difluoroacetic acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 19F, 31P) and chromatographic purity assessment. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
1H NMR	Conforms to structure
19F NMR	Conforms to structure
31P NMR	Conforms to structure
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.